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175 Biomarkers for whole-body health

Unlock a greater understanding of your health with Preamble’s comprehensive biomarker testing. We measure up to 175 key indicators to give you a complete picture of how your body is performing.

Plus, you’ll meet with a real Preamble provider to review your results, so you won’t have to interpret an impersonal AI report on your own.

What’s Included

Lab work for up to 175 biomarkers

Take a deep dive into your health with measurements not typically included in a standard physical, including blood sugar and insulin resistance, cardiovascular risk electrolytes, hormones, kidney and liver function, inflammation, and thyroid.

Includes 1 initial draw and 1 mid-year draw.

1:1 consultation with a REAL person, not AI

After your initial annual draw, you’ll have a 20-minute consultation with a Preamble provider who will review your results, answer your questions, and give you actionable insights based on your personal data.

Option to add HRT and GLP-1 support

Add our medication support program for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT), or weight loss GLP-1 medications.*

*Additional fee. Medications not included.

One Simple Process

1

Schedule your test

Book an appointment to visit a lab near you or schedule an in-home visit.

2

Get your blood draw

A quick blood draw and urine sample will give us actionable insights into your health.

3

Meet with the Provider

Meet in-person or virtually to review the results of your initial draw and discuss an action plan.

Get Started

175 Biomarkers

See what your primary care physician doesn’t measure.

  • Apolipoprotein B
    • ApoB counts the number of cholesterol-carrying particles (LDL, remnants, Lp(a)). It’s the most reliable single marker for artery risk and treatment targets.
  • Lipoprotein (a)
    • Lp(a) is an inherited particle that independently raises ASCVD risk, calling for extra vigilance and aggressive prevention. It barely changes with lifestyle and is usually a once-in-a-lifetime test.
  • Total Cholesterol
    • Total cholesterol is the sum of all cholesterol (LDL, HDL, remnants). It’s a blunt tool—a high TC can be “high” just because HDL is high.
  • HDL Cholesterol
    • HDL helps shuttle cholesterol back to the liver (“recycling”). Level is a proxy; function and overall risk matter more.
  • Triglycerides
    • Triglycerides are blood fats that rise with refined carbs, alcohol, and insulin resistance. Lower is generally better and high levels can elevate apoB.
  • LDL-Cholesterol
    • LDL-C is the amount of cholesterol inside LDL (“bad-cholesterol”) particles—the cargo, not the number of trucks. It’s useful, but ApoB tells risk more precisely.
  • Cholesterol/HDLC Ratio
    • Old school cholesterol ratio that often helped gauge overall heart risk.
  • Non-HDL Cholesterol
    • Non-HDL-C = total cholesterol minus HDL, capturing cholesterol in all the “bad” particles (LDL, remnants, Lp(a)). It’s a better risk marker than LDL-C when ApoB isn’t available.
  • Myeloperoxidase*
    • A white-blood-cell enzyme linked to oxidative stress in arteries.
  • Trimethylamine N-oxide
    • A gut-microbiome metabolite from foods like red meat and egg yolks; higher levels are linked to heart/kidney risk.
  • OxLDL*
    • LDL that’s been oxidized (“rusted”)—more likely to irritate artery walls.
  • Lp-PLA2 Activity*
    • An enzyme tied to artery-wall inflammation and plaque activity.
  • TSH
    • TSH is the pituitary “control signal” that tells your thyroid how hard to work. It helps screen and fine-tune thyroid function alongside free T4 and free T3.
  • Free T3
    • Free T3 is the thyroid hormone your cells actually use. Most of it is made by converting T4 into T3. Influences metabolism, energy levels & other physiological processes.
  • Free T4
    • Free T4 is the main hormone the thyroid releases, which your body turns into T3 as needed. It helps show how much hormone your gland is making.
  • Reverse T3*
    • Reverse T3 is an inactive form of thyroid hormone your body makes from T4. It often rises during illness, stress, or calorie deficit as a temporary energy-saving response.
  • TPO Antibodies*
    • TPO antibodies show when the immune system is targeting the thyroid. A positive result helps explain drifting thyroid levels or symptoms.
  • Thyroglobulin Antibodies*
    • Used to check for antibodies against thyroglobulin, which would mean the immune system is damaging thyroid cells.
  • Iodine*
    • Iodine is a key building block of thyroid hormones.
  • ANA (Antinuclear Antibodies)*
    • ANA tests look for antibodies targeting cell nuclei, often seen in autoimmune diseases.
  • Rheumatoid Factor*
    • Rheumatoid factor is an antibody that can indicate rheumatoid arthritis or other autoimmune activity.
  • Amylase*
    • Helps detect salivary disease, pancreatitis, celiac disease, IBD, or tumor growth in amylase-producing tissues.
  • Lipase*
    • Helps detect inflammation in the pancreas and diagnose other health conditions in the biliary system.
  • CA 19-9*
    • A tumor marker sometimes used to monitor pancreatic or biliary conditions.
  • Jona Test*
  • Cardio IQ APOE Genotype*
    • Tests your APOE gene type, which can influence Alzheimer’s risk.
  • MTHFR*
  • Invitae Comprehensive Genetic Risk Panel (163 genes)*
  • Hemoglobin A1c
    • A1C reflects your average blood sugar over ~3 months. Can be very inaccurate (1% off) in ~10–20% of people. Most useful when paired with CGM data.
  • Insulin
    • Shows how hard your body is working to keep fasting sugar normal—an early window into insulin resistance.
  • Uric Acid
    • Uric acid is a breakdown product that, when high, can raise blood pressure and irritate blood vessels and joints. Lower is generally better.
  • Homocysteine
    • Homocysteine is a sulfur-based amino acid; when elevated it’s an endothelial irritant, which can contribute to the development of atherosclerosis. Aim low and steady.
  • Leptin*
  • HOMA-IR Score
    • A calculated score from fasting glucose and insulin that estimates insulin resistance. Lower is better.
  • Glucose
    • A single morning, empty-stomach blood sugar. A simple first look at glucose control.
  • eGFR
    • An estimate of how well your kidneys filter blood; higher is better. It’s calculated from blood tests (creatinine and/or cystatin C).
  • Bun/Creatinine Ratio
    • Helps interpret kidney and hydration status.
  • Sodium
    • The main blood salt; reflects water balance more than salt intake.
  • Potassium
    • Key mineral for nerve and heart rhythm—kept in a tight range.
  • Chloride
    • Sodium’s partner ion that helps with acid–base balance.
  • Carbon Dioxide
    • Mostly reflects bicarbonate, your blood’s acid buffer.
  • Calcium
    • Mineral for bones, nerves, and muscles; much is bound to albumin.
  • Globulin
    • Blood proteins that include antibodies and carrier proteins.
  • Albumin/Globulin Ratio
    • Compares liver-made albumin to immune-related globulins.
  • Bilirubin, Total
    • A breakdown product from old red cells that the liver processes. Mild isolated elevation is often Gilbert’s syndrome (benign).
  • Alkaline Phosphatase
    • Enzyme from bile ducts and bone (also placenta in pregnancy).
  • Selenium*
  • Methylmalonic Acid*
  • Magnesium, RBC*
    • Looks at magnesium inside red cells, which may better reflect body stores than serum. Cramps, sleep, migraines, etc.
  • Vitamin B12 *
    • Supports nerves, brain, and red blood cells. Low B12 can cause fatigue, numbness/tingling, and memory or mood changes.
  • Folate*
    • Needed for DNA repair and blood cell production—especially important in pregnancy.
  • Zinc*
  • Copper*
  • OmegaCheck (EPA+DPA+DHA)
    • A blood test of omega-3s in your red blood cells, reflecting the last 2–3 months. Higher (within target) is linked to heart and inflammation benefits.
  • EPA
    • An omega-3 that helps cool inflammation and can help lower triglycerides.
  • DPA
    • Docosapentaenoic acid (DPA) is an intermediate omega-3 fatty acid between EPA and DHA. It supports anti-inflammatory balance, cardiovascular health, and helps maintain flexible cell membranes.
  • DHA
    • An omega-3 that supports brain, eye, and heart membranes.
  • Omega-3 Total
    • Sum of all omega-3 fats (EPA, DPA, DHA) reflecting overall anti-inflammatory status.
  • Omega-6 Total
    • Sum of omega-6 fats, which the body uses for cell structure.
  • Omega-6/Omega-3 Ratio
    • Balance of inflammatory (omega-6) vs. anti-inflammatory (omega-3) fats.
  • Arachidonic Acid/EPA Ratio
    • Reflects the inflammatory balance between two key fatty acids.
  • Arachidonic Acid
    • An omega-6 fat needed for repair and signaling.
  • Linoleic Acid
    • A common omega-6 fat found in vegetable oils.
  • Vitamin D
    • 25-OH vitamin D is your body’s vitamin D level (storage form). It supports bone, muscle, and immune health. Levels >30 are linked to lower disease risk.
  • High-Sensitivity C-Reactive Protein
    • A sensitive marker of whole-body inflammation; we want it low and steady. Don’t test while sick or right after a hard workout.
  • Ferritin
    • Ferritin is your iron-storage “fuel tank.” Low means the tank is low; high can mean inflammation or iron overload.
  • GGT
    • GGT is a liver enzyme that can rise with liver injury.
  • Albumin
    • Main liver-made protein that keeps fluid in vessels and carries hormones/drugs.
  • AST
    • A liver enzyme that can also rise with hard workouts or muscle injury.
  • ALT
    • ALT is a liver enzyme that rises when the liver is irritated or fatty. It can also bump after hard workouts or illness.
  • Total Protein
    • Sum of albumin + globulins—nutrition + immune proteins.
  • Cystatin C
    • A kidney-function marker less affected by muscle mass than creatinine.
  • Creatinine
    • A muscle-waste marker filtered by the kidneys—higher usually means lower kidney filtering (affected by creatine usage and muscle mass).
  • BUN (Blood Urea Nitrogen)
    • A protein-waste marker that rises with dehydration and drops when diluted—used with creatinine to check kidney/hydration status.
  • Gravity (urine)
    • Measures how concentrated urine is. High = dehydration; low = overhydration or impaired kidneys.
  • PH (urine)
    • Reflects acidity or alkalinity.
  • Glucose (urine)
    • Detects sugar spillover, often from high blood sugar or diabetes.
  • Bilirubin (urine)
    • May appear if the liver or bile system is under strain.
  • Ketones (urine)
    • Seen in fasting, low-carb diets, or uncontrolled diabetes.
  • Occult Blood (urine)
    • Detects traces of blood not visible to the eye. Can come from infection, kidney stones, or exercise.
  • Protein (urine)
    • Checks for albumin or other proteins. Persistent elevation may signal kidney stress or damage.
  • Nitrite (urine)
    • Indicates nitrite producing bacteria — often seen in urinary tract infections (UTIs).
  • Leuokcyte Esterare (urine)
    • Suggests white blood cells in urine, a common UTI indicator.
  • WBC (urine)
    • White blood cells under the microscope. An infection or inflammation marker.
  • RBC (urine)
    • Red blood cells in urine may mean irritation, stones, or infection.
  • Squamous Epithelial Cells (urine)
    • Surface cells from the urinary tract. Small amounts are normal, high may mean sample contamination.
  • Transitional Epithelial Cells (urine)
    • Cells from the bladder lining. Large numbers can reflect irritation or injury.
  • Renal Epithelial Cells (urine)
    • Cells from kidney tubules; their presence can suggest kidney injury.
  • Bacteria (urine)
    • Indicates bacterial presence.
  • Calcium Oxalate Crystals (urine)
    • Common urinary crystals. May increase with dehydration or kidney stone risk.
  • Triple Phosphate Crystals (urine)
    • Appear in alkaline urine, often with infection.
  • Uric Acid Crystals (urine)
    • Form in acidic urine; linked to gout or kidney stones.
  • Amorphous Sediment (urine)
    • Unstructured crystal deposits.
  • Crystals (urine)
    • General term for solid particle.
  • Hyaline Cast (urine)
    • Tube-shaped protein molds from kidney tubules.
  • Granular Cast (urine)
    • Casts containing cell debris.
  • Casts (urine)
    • General category for tubular structures; type defines significance.
  • Yeast (urne)
    • Presence may suggest a fungal infection.
  • Albumin, Urine
    • Detects small amounts of protein in urine.
  • Estradiol
    • Estradiol is the main estrogen. It supports mood, bone, heart, and (in women) healthy cycles; men make small amounts from testosterone.
  • FSH (Follicle-Stimulating Hormone)
    • FSH is a brain signal that helps ovaries make eggs and testes make sperm. It’s key for fertility and menopause/ovarian reserve clues.
  • LH (Luteinizing Hormone)
    • LH is a brain signal that triggers ovulation in women and tells the testes to make testosterone in men.
  • Progesterone
    • Progesterone rises after ovulation and supports the uterine lining; it also balances estrogen’s effects.
  • AMH*
  • DHEA Sulfate
    • DHEA-S is a steady marker of androgen output from your adrenal glands. It can influence downstream testosterone (and, by conversion, estrogen), so it’s useful when tuning overall hormone balance.
  • Prolactin*
    • Prolactin is a hormone from the pituitary gland that supports milk production. Elevated levels can disrupt cycles, libido, or testosterone balance.
  • Sex Hormone Binding Globulin
    • SHBG is a carrier protein that locks up some testosterone and estradiol. It strongly influences how much hormone is actually available.
  • Free Testosterone
    • The unbound, active form of testosterone in the body. This is directly measured and more accurate than calculated free testosterone. Influences physiological function such as libido, muscle strength & mood.
  • Total Testosterone
    • Total testosterone is the overall amount of testosterone circulating in your blood. It’s the broad first check for hormone status affecting energy, libido, mood, muscle, and body composition.
  • Sex Hormone Binding Globulin
    • SHBG is a carrier protein that locks up some testosterone and estradiol. It strongly influences how much hormone is actually available.
  • Free Testosterone
    • The unbound, active form of testosterone in the body. This is directly measured and more accurate than calculated free testosterone. Influences physiological function such as libido, muscle strength & mood.
  • Total Testosterone
    • Total testosterone is the overall amount of testosterone circulating in your blood. It’s the broad first check for hormone status affecting energy, libido, mood, muscle, and body composition.
  • Estradiol
    • Estradiol is the main estrogen. It supports mood, bone, heart, and (in women) healthy cycles; men make small amounts from testosterone.
  • FSH (Follicle-Stimulating Hormone)
    • FSH is a brain signal that helps ovaries make eggs and testes make sperm. It’s key for fertility and menopause/ovarian reserve clues.
  • LH (Luteinizing Hormone)
    • LH is a brain signal that triggers ovulation in women and tells the testes to make testosterone in men.
  • DHEA Sulfate
    • DHEA-S is a steady marker of androgen output from your adrenal glands. It can influence downstream testosterone (and, by conversion, estrogen), so it’s useful when tuning overall hormone balance.
  • PSA Total
    • A prostate protein used for screening and monitoring—not cancer-specific. Discuss pros/cons and test consistently over time.
  • PSA Free*
  • Prolactin*
    • Prolactin is a hormone from the pituitary gland that supports milk production. Elevated levels can disrupt cycles, libido, or testosterone balance.
  • Absolute Band Neutrophils
    • Early white blood cells released during infection or inflammation.
  • Absolute Metamyelocytes
    • Very immature white blood cells.
  • Absolute Myelocytes
    • Another early-stage white blood cell form.
  • Absolute Promyelocytes
    • Even more immature precursors.
  • Absolute Monocytes
    • Measures monocytes, the cells that clean up debris and fight infections.
  • Absolute Blasts
    • Immature precursor cells not normally in circulation.
  • Absolute Nucleated Rbc
    • Red cell precursors that usually stay in bone marrow.
  • Band Neutrophils
    • Immature neutrophils (“bands”).
  • Metamyelocytes
    • Stages of immature white cells.
  • Myelocytes
    • Various stages of immature white cells.
  • Promyelocytes
    • Various stages of immature white cells.
  • Lymphocytes
    • White blood cells that drive immune memory and viral defense.
  • Reactive Lymphocytes
    • Activated lymphocytes seen in viral infections or immune reactions.
  • Monocytes
    • Long-lived white cells that clear infection and support healing.
  • Blasts
    • Early immature marrow cells; normally absent.
  • Nucleated Rbc
    • Immature red cells.
  • White Blood Cell Count
    • White blood cells are your infection-fighting cells. Levels can swing with illness, stress, medicines, and inflammation.
  • Red Blood Cell Count
    • The number of red blood cells in a set amount of blood. Useful together with hemoglobin, hematocrit, and indices.
  • Hemoglobin
    • The oxygen-carrying protein in red blood cells—screens for anemia or high red cell counts.
  • Hematocrit
    • The percentage of your blood that’s red cells. It helps screen for anemia (low) or too many red cells (high).
  • MCV
    • Average size of your red blood cells. It helps sort out the type of anemia (if present).
  • MCH
    • Average amount of hemoglobin per red cell.
  • MCHC
    • How concentrated hemoglobin is inside each red cell. It adds context to MCV for the type of anemia.
  • Rdw
    • Shows how varied your red cell sizes are.
  • Platelet Count
    • Platelets help your blood clot. Too few raises bleeding risk; too many can raise clot risk.
  • Mpv
    • Reflects average platelet size.
  • Absolute Neutrophils
    • Core infection-fighting white cells; high in bacterial infections, low with some meds or viral illness.
  • Absolute Lymphocytes
    • Counts of each white cell subtype; changes reflect infection, allergy, or inflammation type.
  • Absolute Eosinophils
    • Counts of Eosinophils; changes reflect infection, allergy, or inflammation type.
  • Absolute Basophils
    • Counts of each white cell subtype; changes reflect infection, allergy, or inflammation type.
  • Neutrophils
    • Percentages of Neutrophils within the total white count.
  • Eosinophils
    • Percentages of Eosinophils within the total white count.
  • Basophils
    • Percentages of Basophils within the total white count.
  • Iron, Total*
    • The total amount of circulating iron bound to transport proteins.
  • Iron, Binding Capacity*
    • Measures your blood’s ability to carry iron.
  • Iron % Saturation*
    • Percentage of binding sites filled with iron.
  • Blood Type*
    • Your basic blood type (A, B, AB, or O), important for transfusions.
  • Lyme disease*
  • Galleri by Grail*
    • Galleri® is a multi-cancer early detection test, a blood test that screens for many of the deadliest cancers before they become symptomatic, 1, 2, 3 including those with no recommended screening tests today.
  • Trichomonas*
    • Detects Trichomonas vaginalis infection (parasite).
  • Chlamydia / N. Gonorrhoeae*
    • Detects Chlamydia trachomatis and Neisseria gonorrhoeae infections.
  • HSV 1/2 IgG, Type Specific Antibody*
    • Identifies type-specific antibodies for herpes simplex virus 1 and 2.
  • HIV 1/2 Antigen/Antibody, Fourth Generation with Reflex*
    • Screens for HIV-1/2 infection with high sensitivity (4th generation).
  • RPR (DX) with Reflex Titer and Confirmatory Testing*
    • Syphilis screening with reflex titer and confirmatory testing.
  • Syphillis*
    • Screens for antibodies to Treponema pallidum, the bacterium causing syphilis.
  • Hepatitis B*
    • Detects viral antigens or antibodies to check for current or past hepatitis B infection.
  • Hepatitis C*
    • Screens for antibodies or viral RNA to detect hepatitis C infection.
  • Mercury, Blood*
    • A heavy metal from large predatory fish, some jobs, and older dental materials. Blood/urine reflect recent exposure.
  • Lead (venous)*
    • A toxic metal with no safe level—from old paint/plumbing, hobbies, or some spices/ceramics. Can potentially impact the brain, kidneys, and heart.
  • Arsenic, Blood*
    • Exposure can come from well water, rice, industry, and seafood (which contains mostly non-toxic organic arsenic).
  • Aluminum, Blood*
    • Tests aluminum exposure from cookware, deodorants, medications, etc.
  • BPA Exposure*
    • BPA is a chemical found in plastics and food linings that can act as a hormone disruptor. Testing helps assess exposure risk.
  • Cortisol
    • The body’s main stress hormone. It follows a daily rhythm and helps regulate energy, blood sugar, and inflammation.

* Tests Available at Additional Cost

Get Clear Insights Into Your Health for only $650

PREAMBLE CORE Membership

$54

/Month

*charged annually at $650

Get Started

Measure up to 175 biomarkers

Take a deep-dive into your health with measurements not typically included in a standard physical.

Meet with a REAL person , not AI

We review your results, answer your questions, and give you actionable insights based on your personal data.

Add HRT and GLP-1 support

Support for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT), and weight loss GLP-1 medications.*

*Additional fee. Medications not included.

Questions about the Preamble Core Membership

What does the Preamble Core Membership include?
  • Measure 160+ biomarkers over the course of a year
    • 1 initial draw and 1 mid-year draw
  • Member-only rates on repeat testing and other blood tests not covered by Core Membership
  • Annual review of your tests with a Preamble provider – not AI
  • Access to support for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT) and weight loss GLP-1 medications*

*HRT and GLP-1 support is an additional $100/month plus the cost of medications. Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

Anyone starting on a health journey, seeking foundational health benchmarks, or looking for basic HRT, TRT, or GLP-1 support.

Yes, we do! You can add medication support to your Core Membership for an additional $100/month, plus the cost of medications. 

Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

Yes, we do! You can add medication support to your Core Membership for an additional $100/month, plus the cost of medications. 

Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

No, but all Preamble services and memberships are HSA/FSA eligible.

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