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Preamble Core Membership

Health Data From Humans, Not AI

$650/yr

$54/month, charged annually

Unlock a greater understanding of your health with Preamble's comprehensive biomarker testing. We measure up to 175 key indicators to give you a complete picture of how your body is performing.

Plus, you'll meet with a real Preamble provider to review your results, so you won't have to interpret an impersonal AI report on your own.

Optional add-on: HRT, TRT, and GLP-1 medication support — $100/month plus medication costs.

Preamble clinician drawing blood from a patient for lab testing

What's included

Lab work for up to 175 biomarkers

Take a deep dive into your health with measurements not typically included in a standard physical, including blood sugar and insulin resistance, cardiovascular risk, electrolytes, hormones, kidney and liver function, inflammation, and thyroid. Includes 1 initial draw and 1 mid-year draw.

1:1 consultation with a REAL person, not AI

After your initial annual draw, you'll have a 20-minute consultation with a Preamble provider who will review your results, answer your questions, and give you actionable insights based on your personal data.

Option to add HRT and GLP-1 support

Add our medication support program for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT), or weight loss GLP-1 medications.*

*Additional fee. Medications not included.

One simple process

1

Schedule your test

Book an appointment to visit a lab near you or schedule an in-home visit.

2

Get your blood draw

A quick blood draw and urine sample will give us actionable insights into your health.

3

Meet with the Provider

Meet in-person or virtually to review the results of your initial draw and discuss an action plan.

See what your primary care physician doesn't measure

We go far beyond the standard physical, testing up to 175 biomarkers across 20 categories — giving you a complete picture of how your body is actually functioning.

Heart / Cardiovascular Health 12
Apolipoprotein B

Counts the number of cholesterol-carrying particles for artery risk assessment.

Lipoprotein (a)

Inherited particle that independently raises cardiovascular disease risk.

Total Cholesterol

Sum of all cholesterol types; blunt screening tool.

HDL Cholesterol

Helps transport cholesterol back to the liver for recycling.

Triglycerides

Blood fats that rise with refined carbs and alcohol; elevation can increase risk.

LDL Cholesterol

Cholesterol cargo within LDL particles; useful but less precise than ApoB.

Cholesterol/HDLC Ratio

Traditional metric for gauging overall heart risk.

Non-HDL Cholesterol

Captures cholesterol in all "bad" particles when ApoB is unavailable.

Myeloperoxidase*

White blood cell enzyme linked to oxidative stress in arteries.

Trimethylamine N-oxide

Gut metabolite linked to cardiovascular and kidney risk.

OxLDL*

Oxidized LDL more likely to irritate artery walls.

Lp-PLA2 Activity*

Enzyme tied to artery inflammation and plaque activity.

Thyroid 7
TSH

Pituitary control signal regulating thyroid function intensity.

Free T3

Active thyroid hormone your cells actually use for metabolism.

Free T4

Main hormone released by thyroid; converted to T3 as needed.

Reverse T3*

Inactive form rising during illness, stress, or calorie deficiency.

TPO Antibodies*

Indicates immune system targeting thyroid tissue.

Thyroglobulin Antibodies*

Detects immune damage to thyroid cells.

Iodine*

Essential building block for thyroid hormone production.

Autoimmunity 2
ANA (Antinuclear Antibodies)*

Antibodies targeting cell nuclei, often seen in autoimmune diseases.

Rheumatoid Factor*

Antibody potentially indicating rheumatoid arthritis or autoimmune activity.

Pancreas 3
Amylase*

Detects salivary disease, pancreatitis, celiac disease, IBD, or tumors.

Lipase*

Identifies pancreatic inflammation and biliary system conditions.

CA 19-9*

Tumor marker for monitoring pancreatic or biliary conditions.

Gut Health 1
Jona Test*

Detailed gut microbiome analysis with personalized insights.

Dementia 1
Cardio IQ APOE Genotype*

Tests gene type influencing Alzheimer's risk.

Genetic 2
MTHFR*

Gene affecting folate and homocysteine processing; variants reduce enzyme efficiency.

Invitae Comprehensive Genetic Risk Panel*

Assesses individuals for hereditary conditions including cancers, cardiovascular and metabolic diseases — 163 genes analyzed.

Metabolic Health 18
Hemoglobin A1c

Reflects average blood sugar over approximately 3 months.

Insulin

Shows metabolic effort maintaining fasting blood sugar; early resistance indicator.

Uric Acid

Breakdown product; elevated levels raise blood pressure and vessel irritation.

Homocysteine

Sulfur-based amino acid; elevated levels irritate blood vessel linings.

Leptin*

Fat cell hormone signaling fullness; high levels indicate potential resistance.

HOMA-IR Score

Calculated score estimating insulin resistance.

Glucose

Single morning fasting blood sugar measurement.

eGFR

Kidney filtration efficiency estimate; higher indicates better function.

Bun/Creatinine Ratio

Interprets kidney and hydration status.

Sodium

Main blood salt reflecting water balance.

Potassium

Mineral maintaining nerve and heart rhythm within tight ranges.

Chloride

Ion supporting acid-base balance with sodium.

Carbon Dioxide

Reflects bicarbonate, the blood's acid buffer system.

Calcium

Mineral essential for bones, nerves, and muscles.

Globulin

Blood proteins including antibodies and carrier proteins.

Albumin/Globulin Ratio

Compares liver-made albumin to immune-related globulins.

Bilirubin, Total

Red cell breakdown product processed by the liver.

Alkaline Phosphatase

Enzyme from bile ducts and bone tissue.

Nutrients & Minerals 18
Selenium*

Trace mineral crucial for thyroid hormone activation and antioxidant defense.

Methylmalonic Acid*

Sensitive B12 status marker; elevated indicates functional deficiency.

Magnesium, RBC*

Red cell magnesium reflecting body stores more accurately than serum.

Vitamin B12*

Supports nerves, brain, and red blood cells.

Folate*

Essential for DNA repair and blood cell production.

Zinc*

Mineral supporting immune function, wound healing, and hormone balance.

Copper*

Works with iron for red blood cell and energy production.

OmegaCheck (EPA+DPA+DHA)

Red blood cell omega-3 profile reflecting the last 2–3 months.

EPA

Omega-3 that helps cool inflammation and lower triglycerides.

DPA

Intermediate omega-3 supporting anti-inflammatory balance and cell membrane flexibility.

DHA

Omega-3 supporting brain, eye, and heart cell membranes.

Omega-3 Total

Sum of all omega-3 fats indicating anti-inflammatory status.

Omega-6 Total

Sum of omega-6 fats used for cell structure.

Omega-6/Omega-3 Ratio

Balance between inflammatory and anti-inflammatory fats.

Arachidonic Acid/EPA Ratio

Reflects inflammatory balance between two key fatty acids.

Arachidonic Acid

Omega-6 fat needed for repair and signaling.

Linoleic Acid

Common omega-6 fat found in vegetable oils.

Vitamin D

Storage form supporting bone, muscle, and immune health.

Inflammation 2
High-Sensitivity C-Reactive Protein

Sensitive whole-body inflammation marker; lower is preferred.

Ferritin

Iron storage indicator; elevation suggests inflammation or iron overload.

Liver 5
GGT

Liver enzyme rising with hepatic injury.

Albumin

Primary liver-produced protein maintaining vessel fluid and hormone transport.

AST

Liver enzyme also rising with hard workouts or muscle injury.

ALT

Liver enzyme that rises when the liver is irritated or fatty.

Total Protein

Sum of albumin and globulins representing nutrition and immunity proteins.

Kidneys 28
Cystatin C

Kidney function marker less affected by muscle mass than creatinine.

Creatinine

Muscle-waste marker filtered by kidneys; higher indicates lower filtration.

BUN (Blood Urea Nitrogen)

Protein-waste marker rising with dehydration.

Gravity (urine)

Measures urine concentration; high indicates dehydration.

pH (urine)

Reflects acidity or alkalinity level.

Glucose (urine)

Detects sugar spillover from elevated blood sugar or diabetes.

Bilirubin (urine)

Appears when liver or bile system is stressed.

Ketones (urine)

Seen in fasting, low-carb diets, or uncontrolled diabetes.

Occult Blood (urine)

Detects non-visible blood traces from infection, stones, or exercise.

Protein (urine)

Checks for albumin; persistent elevation may signal kidney stress.

Nitrite (urine)

Indicates nitrite-producing bacteria; often present in urinary tract infections.

Leukocyte Esterase (urine)

Suggests white blood cells; common UTI indicator.

WBC (urine)

Microscopic white blood cells; infection or inflammation marker.

RBC (urine)

Red blood cells suggesting irritation, stones, or infection.

Squamous Epithelial Cells (urine)

Urinary tract surface cells; excess may indicate contamination.

Transitional Epithelial Cells (urine)

Bladder lining cells; high numbers reflect irritation or injury.

Renal Epithelial Cells (urine)

Kidney tubule cells; presence suggests possible kidney injury.

Bacteria (urine)

Indicates bacterial presence.

Calcium Oxalate Crystals (urine)

Common crystals potentially increasing with dehydration.

Triple Phosphate Crystals (urine)

Appear in alkaline urine, often associated with infection.

Uric Acid Crystals (urine)

Form in acidic urine; linked to gout or kidney stones.

Amorphous Sediment (urine)

Unstructured crystal deposits.

Crystals (urine)

General solid particle category.

Hyaline Cast (urine)

Tube-shaped protein molds from kidney tubules.

Granular Cast (urine)

Casts containing cell debris.

Casts (urine)

Tubular structures; type determines significance.

Yeast (urine)

Presence suggests possible fungal infection.

Albumin, Urine

Detects small protein amounts in urine.

Women's Health 10
Estradiol

Main estrogen supporting mood, bone, heart, and healthy cycles.

FSH (Follicle-Stimulating Hormone)

Brain signal helping ovaries produce eggs.

LH (Luteinizing Hormone)

Brain signal triggering ovulation in women.

Progesterone

Hormone rising post-ovulation; supports uterine lining and balances estrogen.

AMH*

Ovarian follicle marker reflecting egg reserve and fertility potential.

DHEA Sulfate

Steady adrenal androgen marker influencing testosterone and estrogen.

Prolactin*

Pituitary hormone supporting milk production; elevation disrupts cycles.

Sex Hormone Binding Globulin

Carrier protein regulating hormone availability.

Free Testosterone

Unbound active testosterone directly measured and more accurate.

Total Testosterone

Overall circulating testosterone affecting energy, libido, and mood.

Men's Health 10
Sex Hormone Binding Globulin

Carrier protein regulating hormone availability.

Free Testosterone

Unbound active testosterone directly measured and more accurate.

Total Testosterone

Overall circulating testosterone affecting energy, libido, and mood.

Estradiol

Main estrogen supporting mood, bone, and heart function.

FSH (Follicle-Stimulating Hormone)

Brain signal helping testes produce sperm.

LH (Luteinizing Hormone)

Brain signal telling testes to make testosterone.

DHEA Sulfate

Steady adrenal androgen marker influencing testosterone and estrogen.

PSA Total

Prostate protein used for screening and monitoring over time.

PSA Free*

Unbound prostate antigen fraction; ratio distinguishes benign from higher-risk changes.

Prolactin*

Pituitary hormone; elevation disrupts testosterone balance.

Blood Health & Anemia 37
White Blood Cell Count

Infection-fighting cells; levels vary with illness and inflammation.

Red Blood Cell Count

Number of red cells; useful alongside hemoglobin and hematocrit.

Hemoglobin

Oxygen-carrying protein in red cells; screens for anemia.

Hematocrit

Percentage of blood that's red cells; screens for anemia or high counts.

MCV

Average red cell size helping classify anemia type.

MCH

Average hemoglobin per red cell.

MCHC

Hemoglobin concentration inside red cells; adds anemia classification context.

RDW

Shows variation in red cell sizes.

Platelet Count

Platelets help your blood clot; too few raises bleeding risk.

MPV

Average platelet size indicator.

Neutrophils

Neutrophil percentage within total white count.

Absolute Neutrophils

Core infection-fighting cells; high in bacterial infection.

Lymphocytes

White blood cells driving immune memory and viral defense.

Absolute Lymphocytes

White cell subtype counts reflecting infection or inflammation type.

Monocytes

Long-lived cells clearing infection and supporting healing.

Absolute Monocytes

Measures cleanup and infection-fighting monocytes.

Eosinophils

Eosinophil percentage within total white count.

Absolute Eosinophils

White cell counts reflecting infection, allergy, or inflammation.

Basophils

Basophil percentage within total white count.

Absolute Basophils

White cell subtype counts reflecting infection or inflammation.

Band Neutrophils

Immature neutrophil forms released during infection or inflammation.

Absolute Band Neutrophils

Early white blood cells released during infection or inflammation.

Metamyelocytes

Immature white cell developmental stages.

Absolute Metamyelocytes

Very immature white blood cells.

Myelocytes

Immature white cell developmental stages.

Absolute Myelocytes

Early-stage white blood cell form.

Promyelocytes

Immature white cell developmental stages.

Absolute Promyelocytes

Even more immature precursor cells.

Reactive Lymphocytes

Activated lymphocytes in viral infections or immune reactions.

Blasts

Early immature marrow cells; normally absent.

Absolute Blasts

Immature precursor cells normally absent from circulation.

Nucleated RBC

Immature red cells.

Absolute Nucleated RBC

Red cell precursors typically remaining in bone marrow.

Iron, Total*

Total circulating iron bound to transport proteins.

Iron, Binding Capacity*

Blood's ability to carry iron measurement.

Iron % Saturation*

Percentage of binding sites filled with iron.

Blood Type*

Basic blood type (A, B, AB, or O); important for transfusions.

Infectious Disease 1
Lyme Disease*

Tests for antibodies that confirm exposure or infection from tick-borne bacteria.

Cancer Detection 1
Galleri by Grail*

Multi-cancer early detection test screening for many deadly cancers before symptoms appear.

Sexual Health 8
Trichomonas*

Detects Trichomonas vaginalis parasitic infection.

Chlamydia / N. Gonorrhoeae*

Detects two bacterial sexually transmitted infections.

HSV 1/2 IgG, Type Specific Antibody*

Identifies herpes simplex virus 1 and 2 antibodies.

HIV 1/2 Antigen/Antibody, Fourth Generation with Reflex*

High-sensitivity HIV screening.

RPR (DX) with Reflex Titer and Confirmatory Testing*

Syphilis screening with confirmation.

Syphilis*

Screens for Treponema pallidum antibodies.

Hepatitis B*

Detects viral antigens or antibodies for current or past infection.

Hepatitis C*

Screens for antibodies or viral RNA detecting hepatitis C.

Toxins & Heavy Metals 5
Mercury, Blood*

Heavy metal from fish, occupations, or dental materials; reflects recent exposure.

Lead (venous)*

Toxic metal with no safe level; from old paint, plumbing, or hobbies.

Arsenic, Blood*

Exposure from well water, rice, industry, or seafood sources.

Aluminum, Blood*

Tests exposure from cookware, deodorants, and medications.

BPA Exposure*

Chemical in plastics and food linings; potential hormone disruptor assessment.

Stress & Aging 1
Cortisol

Main stress hormone following daily rhythm; regulates energy, blood sugar, and inflammation.

Get Clear Insights Into Your Health for only $650

Preamble Core Membership
$54 /mo
Billed annually at $650
Join Preamble

HSA/FSA eligible · No insurance accepted

Measure up to 175 biomarkers

Take a deep-dive into your health with measurements not typically included in a standard physical.

Meet with a REAL person, not AI

We review your results, answer your questions, and give you actionable insights based on your personal data.

Add HRT and GLP-1 support

Support for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT), and weight loss GLP-1 medications.

*Additional fee. Medications not included.

Questions about the Preamble Core Membership

Everything you need to know about Preamble — from how to get started to pricing, insurance, and what to expect.

What does the Preamble Core Membership include?
  • Measure 160+ biomarkers over the course of a year — 1 initial draw and 1 mid-year draw
  • Member-only rates on repeat testing and other blood tests not covered by Core Membership
  • Annual review of your tests with a Preamble provider — not AI
  • Access to support for Hormone Replacement Therapy (HRT), Testosterone Replacement Therapy (TRT) and weight loss GLP-1 medications*

*HRT and GLP-1 support is an additional $100/month plus the cost of medications. Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

Who would benefit from the Preamble Core Membership?

Anyone starting on a health journey, seeking foundational health benchmarks, or looking for basic HRT, TRT, or GLP-1 support.

Does Preamble offer medication support for Hormone Replacement Therapy (HRT) or Testosterone Replacement Therapy (TRT)?

Yes, we do! You can add medication support to your Core Membership for an additional $100/month, plus the cost of medications. Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

Does Preamble offer medication support for GLP-1s?

Yes, we do! You can add medication support to your Core Membership for an additional $100/month, plus the cost of medications. Includes all practitioner visits and up to 2 additional lab visits/draws related to medication support.

Is the Membership covered by insurance?

No, but all Preamble services and memberships are HSA/FSA eligible.

Where is Preamble located?
How do I get started?

Click the Start Testing button below to create an account and book an appointment.

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